This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2023, 19, 231–244, doi:10.3762/bjoc.19.22
Graphical Abstract
Figure 1: Representative drug molecules based on pyrazole, thioamide, and amide derivatives.
Figure 2: Previous and present findings for the synthesis of thioamide derivatives.
Scheme 1: Synthesis of pyrazole C-3-tethered thioamides.
Scheme 2: Synthesis of pyrazole C-4-tethered thioamides.
Scheme 3: Metal- and catalyst-free preparation of pyrazole C-5-linked thioamide conjugates.
Scheme 4: Synthesis of 4-iodopyrazole C-3-tethered thioamides.
Scheme 5: Gram-scale scope of the current protocol.
Scheme 6: Control experiment.
Scheme 7: H2O2-mediated synthesis of pyrazole-pyridine conjugates with amide tethers.
Scheme 8: Synthesis of pyrazole-pyridine conjugates 9F and 10F having amide tethers.
Scheme 9: A tentative mechanism for the formation of pyrazole conjugates with thioamide and amide linkage.
Beilstein J. Org. Chem. 2022, 18, 926–934, doi:10.3762/bjoc.18.92
Figure 1: Few examples of β-carboline-based drugs and bioactive natural products.
Figure 2: 1/3-Formyl-9H-β-carboline: new synthons for the synthesis of β-carboline-fused and substituted fram...
Figure 3: A summary of previous reports toward exploration of 3-formyl-9H-β-carbolines.
Scheme 1: Synthesis of 3-formyl-9H-pyrido[3,4-b]indole derivatives.
Scheme 2: Synthesis of C-3 substituted pyrido[3,4-b]indole MBH derivatives (7 and 8).
Scheme 3: Synthesis of C-3 substituted pyrido[3,4-b]indole MBH derivatives 10.
Figure 4: Library of C-3-substituted pyrido[3,4-b]indole MBH derivatives 7, 8 and 10.
Figure 5: Results of optimization for fluorescence studies: a) contact time; b) concentration; c) solvent.
Figure 6: Pictorial representation of structure–fluorescence activity relationship of C-3 substituted pyrido[...
Beilstein J. Org. Chem. 2020, 16, 1740–1753, doi:10.3762/bjoc.16.146
Figure 1: Representative examples of some commercial drugs and biologically active alkaloids.
Scheme 1: Synthesis of β-carboline-linked 2-nitrochalcones.
Scheme 2: Synthesis of β-carboline-linked benzothiophenone frameworks.
Scheme 3: Comparison of outcome of one-pot vs two-pot approach.
Scheme 4: One-pot synthesis of β-carboline C-1-tethered benzothiophenone derivatives.
Scheme 5: One-pot synthesis of β-carboline C-3-linked benzothiophenone derivatives.
Scheme 6: One-pot synthesis of β-carboline-linked benzothiophene derivative 6C.
Scheme 7: Control experiment in the presence of a radical scavenger.
Figure 2: Proposed reaction mechanism.
Figure 3: Fluorescence spectra of 2aA–nA, 2bB, 2hB, and 6C.
Figure 4: Fluorescence spectra of 4aA–gA, and 4eB.